Blar i forfatter "Staines, Harry"

Viser treff 1-3 av 3

    • The Effect of Protease-Activated Receptor-1 (PAR-1) Inhibition on Endothelial-Related Biomarkers in Patients with Coronary Artery Disease 

      Nilsen, Dennis W.T.; Røysland, Michelle; Ueland, Thor; Aukrust, Pål; Michelsen, Annika Elisabet; Staines, Harry; Barvik, Ståle; Kontny, Frederic; Nordrehaug, Jan Erik; Bonarjee, Vernon V S (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-10-20)
      Abstract Background: Vorapaxar has been shown to reduce cardiovascular mortality in postmyocardial infarction (MI) patients. Pharmacodynamic biomarker research related to protease-activated receptor-1 (PAR-1) inhibition with vorapaxar in humans has short follow-up (FU) duration and is mainly focused on platelets rather than endothelial cells. Aim: This article assesses systemic changes in ...

    • Procollagen type 1 N-terminal propeptide is associated with adverse outcome in acute chest pain of suspected coronary origin 

      Andersen, Thomas; Ueland, Thor; Aukrust, Pål; Nilsen, Dennis WT; Grundt, Magnea Heidi Jonsdottir; Staines, Harry; Pønitz, Volker; Kontny, Frederic (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-09-04)
      Background: Extracellular matrix (ECM) is an integral player in the pathophysiology of a variety of cardiac diseases. Cardiac ECM is composed mainly of collagen, of which type 1 is the most abundant with procollagen type 1 N-terminal Propeptide (P1NP) as a formation marker. P1NP is associated with mortality in the general population, however, its role in myocardial infarction (MI) is still uncertain, ...

    • Vitamin D Uptake in Patients Treated with a High-Dosed Purified Omega-3 Compound in a Randomized Clinical Trial Following an Acute Myocardial Infarction. 

      Næsgaard, Patrycja; Grundt, Heidi; Nordøy, Arne; Staines, Harry; Nilsen, Dennis W.T. (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-07-24)
      Background: <br> Fish is the natural dietary source of vitamin D. Reports on the influence of purified omega-3 fatty acids on its uptake are scarce. <br> Objectives: <br> We investigated the impact of a purified high-dose omega-3 compound compared to corn oil on 25-hydroxyvitamin D [25(OH)D] levels following an acute myocardial infarction. <br> Methods: <br> 228 patients were randomized 1:1 to receive ...